NKX2.2 (Neuroendocrine & Ewing’s Sarcoma Marker)

Formalin fixed paraffin embedded human Ewing’s sarcoma stained with Diagnostic Biosystems NKX2.2 (Catalog number RMAB085)

  • CloneDBR16.3
  • IsotypeIgG
  • ImmunogenRecombinant human NKX2.2 protein fragment
  • SpeciesRabbit
  • SummaryExpression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
  • Cellular LocalizationNuclear
  • Positive Control TissuePancreas, Ewing’s sarcoma
  • Concentrated Dilution1:50-1:100
  • PretreatmentEDTABuffer pH 8.0
  • Incubation & Temperature30 min @ RT
  • Detection SystemPolyVue™ Plus - Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System
  • Intended UseIVD
  • Description/TypeFFPE
Catalog No Volume
RMAB085Concentrated 1 ml
RMPD085Prediluted 6 ml
RMPD085-10RMPrediluted 10 ml
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