Calretinin

Calretinin is a nuclear and cytoplasmic stain which stains a wide variety of tissues including adipocytes, endometrial stromal cells, Sertoli- Leydig cells, and mast cells, but is used primarily to identify mesothelial cells. Both benign and malignant mesothelial cells are positive, whereas adenocarcinomas are negative. When used in a body fluid panel with adenocarcinoma markers such as MOC-31, B72.3 and Ber EP4 it can be very useful to separate reactive (benign) mesothelial cells from metastatic adenocarcinoma. Similarly, it is used to separate epithelial mesothelioma from adenocarcinoma. It can also be used to differentiate Schwannoma (+ve) from neurofibroma (-ve).

• Differentiate epithelioid pleural mesothelioma (+ve) from lung adenocarcinoma (-ve)
• Differentiate epithelioid peritoneal mesothelioma (+ve) from ovarian serous papillary carcinoma (-ve)
• Differentiate mesothelioma (+ve) from metastatic renal cell carcinoma (-ve)