Description
The epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane protein consisting of an extracellular EGF-binding domain, a short transmembrane region and an intracellular domain with ligand-activated tyrosine kinase activity. EGFR is expressed in many normal epithelial tissues, particularly in the basal layers of stratified epithelium and in squamous epithelium. Over expression of EGFR has been observed in many types of neoplasia, as a result of gene amplification and/or increased protein transcription.
Additional information
| Catalog No. | Mob461, PDM226, PDM226-10MM |
|---|---|
| Clone | 31G7 |
| Isotype | IgG1 |
| Immunogen | Human EGFR derived from A-431 cell line. |
| Species | Mouse |
| Cellular Localization | cell membrane, Cytoplasmic |
| Positive Control Tissue | Breast carcinoma, Placenta |
| Pretreatment | Proteinase K |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
REFERENCES
REFERENCES
- Christensen et al. Danish Med Bull 45 (2): 121, 1998.
- Niikura et al. Human Pathol 27 (3), 1996.
- Rusch et al. Ann Thorac Surg 62: 798, 1996
Reviews (0)
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.