Description
The epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane protein consisting of an extracellular EGF-binding domain, a short transmembrane region and an intracellular domain with ligand-activated tyrosine kinase activity. EGFR is expressed in many normal epithelial tissues, particularly in the basal layers of stratified epithelium and in squamous epithelium. Over expression of EGFR has been observed in many types of neoplasia, as a result of gene amplification and/or increased protein transcription.
Additional information
| Catalog No. | Mob615, PDM615 |
|---|---|
| Clone | A-10 |
| Isotype | IgG2a |
| Immunogen | A synthetic peptide corresponding to amino acids 1114-1147 at the C-terminus |
| Species | Mouse |
| Cellular Localization | cell membrane, Cytoplasmic |
| Positive Control Tissue | Placenta |
| Pretreatment | EDTA |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
REFERENCES
REFERENCES
- i) Christensen et al. Danish Med Bull 45 (2): 121, 1998.
- ii) Niikura et al. Human Pathol 27 (3), 1996.
- iii) Rusch et al. Ann Thorac Surg 62: 798, 1996.
