This antibody recognizes a protein of 21kDA, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the protolytic invasiveness of tumor cells and normal placental trophoblast cells.
TIMP-2
Catalog No: 5409
Categories: Primary Antibodies, IVD - Outside U.S. Market, RUO - For U.S. Market
Tags: Concentrated, Ready to Use, T
Description
Additional information
Catalog No. | Mob318, Mob318R – Concentrated, PDM318 |
---|---|
Clone | 3A4 |
Isotype | IgG2a, kappa |
Immunogen | BALB/C mice were injected with a synthetic peptide from the N-terminal region of human TIMP-2. |
Species | Mouse |
Cellular Localization | Cytoplasm and cell surface |
Positive Control Tissue | Breast, Colon, Endometrial, HeLa cells, Normal Placenta, Prostate or Ovarian Carcinoma |
Pretreatment | EDTA Buffer pH 8.0 |
Incubation & Temperature | 30 min @ RT |
Intended Use | IVD, RUO |
Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
Description/Type | Mouse Monoclonal Antibody |
Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
Download Datasheet |
Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Murray et al. 1998. Gut. 43(6):791-7.
- Jeffery et al. 2009. Histopathology. 54(7):820-8
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