Description
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In nonneoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, Uroplakin II/III cocktail is specific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors.
Additional information
| Catalog No. | PDRM002 Prediluted, RPM001 Concentrated |
|---|---|
| Immunogen | UPII: Peptide-KLH conjugate UPIII: Raised in mouse using AUM preparation from bovine urinary bladder as the immunogen. |
| Species | Mouse, Rabbit |
| Cellular Localization | Cytoplasmic and Membranous |
| Positive Control Tissue | Bladder Carcinoma |
| Pretreatment | Tris EDTA Buffer pH9.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit anti-UPII + Mouse anti-UPIII |
| Format | This productissupplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
Reference
Reference
I. Moll R, et al. Uroplakins, specific membrane proteins of urothelial umbrella
cells, as histological markers of metastatic transitional cell carcinomas. Am J
Pathol. 1995; 147:1383-97.
II. Olsburgh J, et al. Uroplakin gene expression in normal human tissues and
locally advanced bladder cancer. J Pathol. 2003; 199:41-9
III. Parker DC, et al. Potential utility of uroplakin III, thrombomodulin, high
molecular weight cytokerain and cytokeratin 20 in noninvasive, invasive, and
metastatic urothelial (transitional cell) carcinomas. Am J Surg Pathol. 2003;
27:1-10
IV. Ohtsuka Y, et al. Loss of uroplakin III expression is associated with a poor
prognosis in patients with urothelial carcinoma of the upper urinary tract.
BJU Int. 2006; 97:1322-6.
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