Lung cancer Awareness

Lung cancer Awareness!

Every breath is a gift, and this Lung Cancer Awareness month, let’s unite to spread awareness about lung cancer. Did you know that lung cancer is the leading cause of cancer-related deaths worldwide?

Lung cancer affects millions of lives worldwide, and early detection is crucial.

Lung cancer has two major types: non-small cell lung cancers (NSCLC) accounting for 80% and small cell lung cancers (SCLC) for 18%. NSCLC has three subtypes: adenocarcinoma (LADC) for 40%, squamous cell carcinoma (SqCC) for 30% and large cell carcinoma for 10%. SCLC account for approximately 20% of lung cancers. They typically begin in the lung’s bronchi and spread quickly, often to other parts of the body. The assessment is critical for correct diagnosis.

A pulmonary panel of antibodies is useful to distinguish types of lung cancer. The patients with SqCC cannot receive Avastin due to a 30% mortality rate as a result of fatal hemoptysis. A panel of p40, Napsin A, CK5/6, TTF-1 can be used to di¬fferentiate LADC from SqCC.

1. p40 is highly specific to squamous cell carcinoma, which is one of the major subtypes of non-small cell lung cancer (NSCLC). Using p40 in IHC staining can help pathologists confirm the presence of squamous cell carcinoma in a lung tumor.
2. p40 is often used in combination with other markers like CK5/6 to enhance the accuracy of the diagnosis. The co-expression of p40 and CK5/6 is a common approach for confirming squamous cell carcinoma.
3. TTF-1 is highly specific to lung adenocarcinoma, one of the most common types of lung cancer. It is also used to differentiate primary lung cancer from metastatic tumors originating in other organs.
4. Napsin A is another marker used to identify lung adenocarcinoma. It can be particularly helpful in cases where TTF-1 results are inconclusive.
5. CD56, Synaptophysin, and Chromogranin A are used to identify small-cell lung carcinoma, a highly aggressive form of lung cancer.

Early and accurate detection saves lives!!!