Description
This antibody reacts with a 70 kD protein known as Ku (p70).The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86). Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp.
Additional information
| Clone | H-6 |
|---|---|
| Isotype | IgG1 |
| Immunogen | Ku-(p70) is a mouse monoclonal antibody specific for an epitope mapping between amino acids 583-608 at the C-terminus of KU70 of human origin. |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Tonsil |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Conc Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Mimori, T., et al. 1986. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.J. Biol. Chem. 261: 2274-2278.
Chan, J.Y.C., et al. 1989. Cloning and characterization of a cDNA that encod
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