Description
The BCL6 gene encodes a 706 amino acid nuclear protein of the Kruppel-type zinc finger protein. It is rearranged in about 30% of diffuse large B-cell lymphomas, and is expressed predominantly in normal germinal centre B cells and related lymphomas. The antibody is a useful aid for classification of follicular lymphomas, diffuse large B-cell lymphomas, Burkitt’s lymphomas, and nodular, lymphocyte-predominance Hodgkin’s lymphoma. The BCL6 antibody, together with BCL2 antibody, is also a useful aid in classification of mantle cell lymphomas, and nodular, lymphocyte-predominance Hodgkin’s lymphoma. BCL6 protein is not expressed in B-CLL, hairy cell leukemia, mantle cell and marginal-zone derived lymphomas
Additional information
| Catalog No. | Mob587 Concentrated, PDM587 Prediluted |
|---|---|
| Clone | PG-B6 |
| Isotype | IgG1, kappa |
| Immunogen | Recombinant protein from the N-terminus of human Bcl-6. |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Flenghi I., et al. Monoclonal antibodies PG-86a and PG-86p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region. Am 1 Pathol 1996,148:1543-55.
- Falini B. et al. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin’s disease. Blood 1996,87:465-71.
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