Description
Anaplastic lymphoma kinase (ALK) known as ALK tyrosine kinase receptor or CD246, is a tyrosine kinase receptor. ALK is an important biomarker for diagnosis of non-small cell lung cancer (NSCLC).
Additional information
| Catalog No. | Mob566, Mob566R – Concentrated, PDM566, PDM566R – Prediluted |
|---|---|
| Clone | 4A4 |
| Isotype | IgG2b |
| Immunogen | Recombinant human ALK protein fragment. |
| Species | Mouse |
| Cellular Localization | Cytoplasmic and nuclear staining |
| Positive Control Tissue | Anaplastic large cell lymphoma |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Conc Mouse Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Schulte JH, et al; High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma. Clin Cancer Res. 17(15):5082-5092
- Martelli MP, et al;. EML4-ALK Rearrangement in Non-Small Cell Lung Cancer and Non-Tumor Lung Tissues. Am J Pathol. 174(2): 661-670
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