Description
This antibody reacts with the active form of caspase 3 (17 kD protein). Caspase 3 is a member of the interleukin-1 beta-converting enzyme family and is thought to be associated with the induction of apoptosis. Caspase 3 is synthesized as an inactive 32 kD proenzyme and is processed during apoptosis generating two subunits of 17 kD and 12 kD. Caspase 3 stains the epithelial cells of skin, renal proximal tubules, and collecting ducts.
Additional information
| Catalog No. | PDR172 Prediluted, RP096 Concentrated |
|---|---|
| Clone | Rabbit |
| Immunogen | A synthetic peptide corresponding to the cleavage site of human caspase 3 (amino acids 167-175), conjugated to KLH. |
| Species | Rabbit |
| Cellular Localization | Cytoplasmic, Some Nuclear |
| Positive Control Tissue | Tonsil |
| Pretreatment | Citrate Buffer pH 6.1 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Polyclonal Anitibody |
| Format | Purified immunoglobulin fraction of rabbit antiserum against Caspase 3 containing sodium azide as a preservative. |
DATASHEETS & SDS
REFERENCES
REFERENCES
- Krajewska et al. Cancer Res 57: 1605, 1997.
- Mallat et al. Circulation 96: 424, 1997.
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