April is Testicular Cancer Awareness Month!

Testicular Cancer Awareness 2024

Testicular cancer is a type of cancer that develops in the testicles, which are part of the male reproductive system. It typically affects younger men, with the highest incidence occurring in those between 15 and 35 years old, though it can occur at any age.

Immunohistochemistry involves using antibodies to detect specific proteins in tissue samples. In testicular cancer, certain markers like OCT3/4, PLAP (placental alkaline phosphatase), CD30, and others are commonly used to identify germ cell tumors.

  1. OCT3/4 is a transcription factor expressed in germ cell tumors, including both seminomas and non-seminomatous germ cell tumors (NSGCTs). Its expression helps differentiate germ cell tumors from other testicular neoplasms.
    Read More: https://bit.ly/OCT-3-4
  2. PLAP (Placental Alkaline Phosphatase): PLAP is a glycoprotein enzyme expressed in germ cell tumors, particularly in seminomas. It is commonly used as a marker to aid in the diagnosis of seminomatous tumors.
    Read More: https://bit.ly/DBS-PLAP
  3. SALL4 is a nuclear marker that is expressed in most of testicular germ cell tumors and germ cell neoplasia in situ.
    Read More: https://bit.ly/SALL4

Testicular cancer is highly treatable, especially when detected early. It’s essential for men to be aware of the signs and symptoms and to perform regular self-examinations of their testicles. Early detection and prompt treatment significantly improve outcomes.