| PATENT | ABSTRACT/SUMMARY | VIEW/DOWNLOAD |
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| UNITED STATES PATENT AND TRADEMARK OFFICE Application No: 16/750, 148 Issue Date: 13 june 2023 Patent No: 11674870 |
U.S. Patent |
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| CHROMOGEN LAYERING FOR COLOR GENERATION Inventor: Bipin Gupta, Pleasanton, CA (US); Marc Key, Ojai, CA (US) Appl. No.: 15/650,940 Filed: Jul. 16,2017 Patent No.: US 10,280,445 B2 Date: May 7, 2019 |
The present disclosure relates method of chromogen layering, wherein a first chromogen and a first stain (color) are produced on a sample, specific for a first analyte, followed by a second chromogen and a second stain (color) being produced on the same sample, specific for a second analyte. In addition, if desired, by overlaying the second stain on top of the first stain, a unique third color is produced that is specific for a third analyte. Therefore, the distribution of different colors throughout the sample could be used to identify at least two or more analytes simultaneously within a single sample. |
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| COUNTERSTAINS FOR A BIOLOGICAL SAMPLE Inventor: Bipin Gupta, Pleasanton, CA (US); Marc Key, Ojai, CA (US) Appl. No.: 15/478,959 Filed: Apr. 4, 2017 Patent No.: US 10,718,694 B2 Date of Patent: July 21, 2020 |
The present disclosure relates to counterstains Ibr staining a biological sample on a single slide in preparation Ibr microscopic examination. The counterstains are used to analyze the sample on the single slide using both brightlield and lluorescent illumination. The counterstains can identilY both morphological details and molecular structures within the cells contained in the sample. […] |
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| DEPARAFFINIZING COMPOSITIONS AND METHODS Inventor: Bipin Gupta, Pleasanton, CA (US); Marc Key, Ojai, CA (US) Appl. No.: 16/111,755 Filed: Aug. 24, 2018 Patent No.: US 10,852,219 B2 Date of Patent: December 1, 2020 |
A deparaffinizing composition and method are provided for removing paraffin wax from biological samples. The deparaffinizing composition may include: a paraffin solvent that may be a first apolar paraffin solvent; a second apolar solvent that may be at least partially miscible with water; a first polar solvent that may be miscible with both water and […] |
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| METHOD FOR LABELING CONCENTRATION DENSITY DIFFERENTIALS OF AN ANALYTE IN A BIOLOGICAL SAMPLE Inventor: Bipin Gupta, Pleasanton, CA (US); Marc Key, Ojai, CA (US) Appl. No.: 15/720,239 Filed: Sep. 29,2017 Patent No.: US 10,379,015 B2 Date of Patent: Aug 13, 2019 |
A method for labeling concentration density differentials of an analyte in a biological sample is provided. The method may including the steps of: binding an enzyme to an analyte contained in a sample, the enzyme capable of acting on at least two chromogens; incubating the sample with a first chromogen for a first time period […] |
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| METHOD OF PRETREATMENT OF BIOLOGICAL SAMPLES FOR AN ANALYTE-STAINING ASSAY METHOD Inventor: Marc Key, Ojai, CA (US); Bipin Gupta, Pleasanton, CA (US) Appl. No.: 15/256,609 Filed: Sep. 4,2016 Patent No.: US 10,281,374 B2 Date: May 7, 2019 |
Disclosed are methods for treating a biological sample for an analyte-staing assay. These methods are conducted with the use of a single aqueous multi-functional composition for the purposes of performing the steps of deparaffinization, rehydration, antigen retrieval and endogenous enzyme blocking simultaneously optionally at an elevated temperature. These methods are alternatively conducted with use of a single aqueous multi-functional composition the contains a thermostable protease for the purpose of deparaffinization, rehydration, antigen retrieval and endogenous enzyme blocking at an elevated temperature. |
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| SEALING FLUID FOR MICROFLUIDIC ANALYSES Inventors: Marc Key, Ojai, CA (US); Bipin Gupta, Pleasanton, CA (US) Appl. No.: 15/379,336 Filed: Dec. 14, 2016 Patent No.: US 10,495,553 B2 Date of Patent: Dec. 3, 2019 |
The present disclosure relates to an aqueous sealing fluid for sealing a stained biological specimen present on a microscope slide for microscopic analysis. The sealing fluid protects the biological specimen from drying artifacts, protects stains performed on biological specimens from fading, and protects stains performed on biological specimens from being dissolved by organic mounting media. […] |