Description
This antibody reacts with adenovirus. The adenovirus early gene product E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth-inhibitory effects of TGF-β. The E1A region encodes a series of related proteins (35-46 kDa) with multifunctional capabilities and forms a specific complex with the retinoblastoma tumor suppressor gene product. The E1A and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region.
Additional information
| Catalog No. | Mob355, Mob355R – Concentrated |
|---|---|
| Clone | M58+M73 |
| Isotype | IgG2a, kappa, kappa; M73, M58 |
| Immunogen | BALB/C mice were injected with adenovirus. |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Adenovirus infected tissue |
| Pretreatment | None |
| Incubation & Temperature | _ |
| Intended Use | IVD, RUO |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Conc Mouse Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- i) Harlow et al. Mol cell Biol 6: 1579, 1986.
- ii) Harlow et al. J Virol 3: 533, 1985.
Klein et al. Science 238: 1539, 1987
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