Description
This antibody recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or over expressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
Additional information
| Clone | 9 E10 |
|---|---|
| Isotype | IgG1 |
| Immunogen | A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLE QLRNSCA) from C-terminus of human c-myc, coupled to KLH |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
REFERENCES
REFERENCES
- Campbell et al. J Biol Chem 267: 9321, 1992.
- Evan et al. Molecular and Cell Biology 5: 3610, 1985.
- Hu et al. Science 268: 100, 1995
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