Description
CD4 is glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It is co-receptor that assists the T-cell receptor (TCR) with antigen-presenting cell and also interacts directly with MHC class II molecules of the surface of antigenpresenting cells. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma. CD4 plays important role in the classification of lymphocytes in inflammatory legions and malignant lymphomas.
Additional information
| Clone | EP204 |
|---|---|
| Isotype | IgG |
| Immunogen | Synthetic peptide corresponding to residues of human CD4 protein. |
| Species | Rabbit |
| Cellular Localization | cell membrane |
| Positive Control Tissue | Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Monoclonal Antibody |
| Format | This productissupplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Brady RL, et al.: Science 1993, 260:979-983
- Sattentau QJ, et al.: Cell 1988, 52:631-633
- Williamson SL, et al.: Am J Pathol 1998, 152:1421-1426
- Dabbs DJ. Diagnostic Immunohistochemistry 2010; Churchill
Livingstone
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