Description
This antibody recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes
(from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Additional information
| Catalog No. | Mob168, PDM033, PDM033-10MM |
|---|---|
| Clone | LN2 |
| Isotype | IgG1, kappa |
| Immunogen | SU-DHL-4 lymphoma cells. |
| Species | Mouse |
| Cellular Localization | cell membrane |
| Positive Control Tissue | Squamous Lung Carcinoma, Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Epstein et al..’ I mmuno1133: 1028, 1984.
- Marder et al. Lab Invest 52:497, 1985.
- Okon et al. Cancer 56: 95, 1985.
- Sher rod a al Cancer 57: 2135,1986.
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