Description
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Additional information
| Clone | 144B |
|---|---|
| Isotype | IgG1, kappa |
| Immunogen | Synthetic peptide comprised of 13 C terminal amino acids from the cytoplasmic domain of the CD8 molecule. |
| Species | Mouse |
| Cellular Localization | cell membrane |
| Positive Control Tissue | Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Mason DY, et. al. Journal of Clinical Pathology, 1992, 5(12):1084- 8.
- Korkusuz, P. et at Immunophenotypk analysis of human spleen compartments. Mn. Mat. 184: 431-441.
- Kutok, J. L et al. Splenic vascular tumors. Semin. Diagn. Pathol. 20: 128-139
Reviews (0)
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.