Description
This antibody recognizes a doublet of 50 kDa and a single band of 42 kDa identified as cyclin E. Cyclin proteins are a family of related proteins, which control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and is modulated by the presence of tumor suppressor proteins such as p16.
Additional information
| Clone | HE12 |
|---|---|
| Isotype | IgG1 |
| Immunogen | Synthetic peptide corresponding to human cyclin E protein. |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | _ |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Conc Mouse Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Dutic et al. Science 257:1958, 1992.
- Dutta et al. Proc. Natl. Mad. Sci. USA, 92:5386, 1995.
- Faha et al, 1 Virol 67: 2456, 1993.
- Gong et al. Cell Proliferation 28:1, 1995.
- Koff et al. Cell 66:1217, 1991.
- Ohtsubo et al. Mol Cell Blot IS: 2612,1995.
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