DOG1 is expressed ubiquitously in gastrointestinal stromal tumors irrespective of c-kit or PDGFR alpha mutation status. Reactivity for DOG1 may aid in the diagnosis of gastrointestinal stromal tumors, including PDGFRA mutants that fail to express c-kit antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the c-kit tyrosine kinase.
DOG 1
Catalog No: 8392
Categories: IVD - For U.S. Market, Primary Antibodies, IVD - Outside U.S. Market
Tags: Concentrated, D, Highlighter Product, HL72K-Core Kit
Description
Additional information
Clone | DOG1.1 |
---|---|
Isotype | IgG |
Immunogen | A synthetic peptide of human DOG1 protein. |
Species | Mouse |
Cellular Localization | cell membrane, Cytoplasmic |
Positive Control Tissue | Gastrointestinal stromal tumor tissue |
Pretreatment | EDTA Buffer pH 8.0 |
Incubation & Temperature | 30 min @ RT |
Intended Use | IVD |
Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
Description/Type | Mouse Monoclonal Antibody |
Format | This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
Download Datasheet |
Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
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