This antibody reacts withwith the first EGF repeat in the extracellular domain of Ep-CAM. It is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
Small cell lung carcinoma cells.
|Positive Control Tissue
Breast carcinoma, Colon carcinoma
EDTA Buffer pH 8.0
|Incubation & Temperature
30 min @ RT
PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System
Mouse Monoclonal Antibody
This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative.
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