Description
This monoclonal antibody is specific to estrogen receptor alpha (ER alpha) and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumorsindicates an increased likelihood ofresponse to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.
Additional information
| Catalog No. | Mob121, PDM048, PDM048-10MM |
|---|---|
| Clone | 6F11 |
| Isotype | IgG1, kappa |
| Immunogen | Recombinantfulllength human Estrogen Receptor alpha protein |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
REFERENCES
REFERENCES
- Zafrani B, et. al. Histopathology 2000; 37(6), 536–545.
- Harvey JM, et. al. Journal of Clinical Oncology 1999;
17(5), 1474–1481.
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