Description
This antibody recognizes a protein of 67kDa, which is identified as estrogen receptor (ER). ER content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Additional information
| Clone | SP1 |
|---|---|
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide derived from C-terminal of human estrogen receptor. |
| Species | Rabbit |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30-60 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Rabbit Monoclonal Antibody |
| Format | This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
REFERENCES
REFERENCES
- i) Hruban et al. Am m J Clin Pathol 88: 578, 1987.
- ii)Naiem et al. J Immunol Meth 50:145, 1982.
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