von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi’s sarcoma and cardiact myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contian this antigen.
Von Willebrand factor isolated from human plasma.
|Positive Control Tissue
EDTA Buffer pH 8.0
|Incubation & Temperature
30 min @ RT
PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System
Mouse Monoclonal Antibody
This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative.
- i) Hruban et al. Am m J Clin Pathol 88: 578, 1987.
- ii)Naiem et al. J Immunol Meth 50:145, 1982.
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