Description
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. AIF1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding AIF1 resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).
Additional information
| Catalog No. | Mob602 Concentrated, PDM602 Prediluted |
|---|---|
| Clone | AIF1 |
| Isotype | IgG1, kappa |
| Immunogen | Purified fragment of human recombinant AIF1 protein (around aa 1-146) (exact sequence is proprietary) |
| Species | Mouse |
| Cellular Localization | Cytoplasmic and Cell Surface |
| Positive Control Tissue | Spleen |
| Pretreatment | Tris EDTA buffer, pH9.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
| Description/Type | Mouse Monoclonal Antibody |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
I. Kelemen SE, Autieri MV. Expression of allograft inflammatory factor-1 in T lymphocytes. Am J Pathol2005; 167: 619-26
Reviews (0)
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.