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Home / Primary Antibodies / IVD - Outside U.S. Market
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Formalin fixed paraffin embedded human Pancreas stained with INSM1 25x.

INSM1 (A-8)

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Catalog No: Mob586- Categories: Primary Antibodies, IVD - For U.S. Market, IVD - Outside U.S. Market Tags: Concentrated, I
PRODUCT CATEGORIES
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Description

INSM1 (insulinoma-associated protein 1), also known as zinc-finger protein IA-1, is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but it can be found highly expressed in neuroendocrine tumors. INSM1 contains five Cys2-His2-type zinc-finger DNA binding domains and a prohormone domain. INSM1 acts as a transcriptional repressor of the Neuro D promoter and recruits cyclin D1 as a corepressor. It plays an importantrole in neuroendocrine development and isrequired for normal differentiation of pancreatic endocrine cells. Inhibition of INSM1 results in decreased formation of glucagon and Insulin positive cells. The gene encoding INSM1 is directly regulated by Neurogenin 3 which binds chromatin in the INSM1 promoter region and induces transcription.

Additional information
Clone

A-8

Isotype

IgG1, kappa

Immunogen

Amino acid 81-125 at the N-terminus of human INSM1

Species

Mouse

Cellular Localization

Nuclear

Positive Control Tissue

neuroendocrine tumor

Pretreatment

EDTA Buffer pH 8.0

Incubation & Temperature

30 min @ RT

Intended Use

IVD

Detection System

PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System

Description/Type

Mouse Monoclonal Antibody

Format

This product is supplied as a immunoglobulin and contains sodium azide as a preservative.

DATASHEETS & SDS

DATASHEETS & SDS

Download Datasheet
Download SDS Sheet – OSHA

Download SDS Sheet – EU

REFERENCES

REFERENCES

  • Li, Q., et al. 1997. Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. Biochem. Biophys. Res. Commun. 236: 776-781. 2.
  • Breslin, M.B., et al. 2002. Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. Nucleic Acids Res. 30: 1038-1045
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