Description
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
Additional information
| Clone | 44 |
|---|---|
| Isotype | IgG1 |
| Immunogen | Human MSH6. |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Colon carcinoma, Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 (Manual/ Montage) |
| Incubation & Temperature | 60 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Frasno et al. Mod Pathol 11: 934, 1998.
- Schleger et al.Exp Cell 236: 418,1997.
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