Description
This antibody reacts with a 1000 kDa protein and recognizesthe peptide core of gastric mucin M1. Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric mucin M1 antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either reexpression of the peptide core of gastric mucin in the adult colon or changes in the glycosylation pattern of mucin, which expose the hidden M1 antigen.
Additional information
| Clone | 45M1 |
|---|---|
| Isotype | IgG1, kappa |
| Immunogen | BALB/C mice were injected with M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le (a-b) patient. |
| Species | Mouse |
| Cellular Localization | cell surface, Cytoplasmic |
| Positive Control Tissue | Stomach |
| Pretreatment | None |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Bara et al. Int J Cancer 47: 304, 1991.
- Bara et al. J Immun Methods 149: 105, 1992.
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