Description
Recognizes a protein of about 50kDa, which is identified as gamma-enolase.
Three isoenzymes of enolases are identified, alpha, beta and gamma. Alphaisoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It is usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.
Additional information
| Catalog No. | Mob616, PDM616 |
|---|---|
| Clone | DBMM4.507 |
| Isotype | IgG2b, kappa |
| Immunogen | Recombinant fragment ofnhuman NSE gamma(around aa 416-433) |
| Species | Mouse |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Pancreas, Cerebellum, Pheochromocytoma |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- . Verma, M., et al. 1994. DNA sequences encoding enolase are remarkably conserved from yeast to mammals. Life Sci. 55: 893-899.
