Recognizes a protein of about 50kDa, which is identified as gamma-enolase. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alphaisoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.
Neuron Specific Enolase (NSE)
Catalog No: Mob212-
Categories: IVD - For U.S. Market, Primary Antibodies, IVD - Outside U.S. Market
Tags: Concentrated, N
Description
Additional information
Catalog No. | Mob212 Concentrated, PDM321 Prediluted |
---|---|
Clone | VI-H14 |
Isotype | IgG1 |
Immunogen | γ-γ enolase from human brain |
Species | Mouse |
Cellular Localization | Cytoplasmic |
Positive Control Tissue | Pancreas, Cerebellum, Pheochromocytoma |
Pretreatment | Citrate Buffer pH 6.0 |
Incubation & Temperature | 30 min @ RT |
Intended Use | IVD |
Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
Description/Type | Mouse Monoclonal Antibody |
Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
Download Datasheet |
Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- . Verma, M., et al. 1994. DNA sequences encoding enolase are remarkably conserved from yeast to mammals. Life Sci. 55: 893-899.
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