P16 is a mitotic inhibitor protein. It competes with D-type cyclins to bind to cdk4 and cdk6. It acts as tumor suppressor and inhibits the progression of cells through the G1 phase of the cell cycle.
Mob575 Concentrated, PDM575 Prediluted
Purified recombinant prokaryotic full length human P16 INK4 protein
Nuclear and Cytoplasmic
|Positive Control Tissue
Uterine cervical squamous cell carcinoma
EDTA Buffer pH8.0
|Incubation & Temperature
30 min @ RT
PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System
Mouse Monoclonal Antibody
Tissue Culture Supernatant
Sherr CJ et al. D-type cyclins and their cyclin-dependent kinases: G1 phase integrators of the mitogenic response. Cold Spring Harb Symp Quant Biol 1994; 59:11–9.
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