Description
p40 is a relatively unknown antibody that recognizes ΔNp63-a p63 isoform suggested to be highly specific for squamous/basal cells. In a recent study, p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity1, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.
Additional information
| Catalog No. | PDR055 Prediluted, RP163 Concentrated |
|---|---|
| Clone | Rabbit |
| Immunogen | A synthetic peptide corresponding to amino acids 5-17 of human p40. |
| Species | Rabbit |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Prostate |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Polyclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Bishop JA, et al. p40 (ΔNp63) is superior to p63 for the diagnosis
of pulmonary squamous cell carcinoma. Mod Pathol.
10.1038/modpathol.2011.173. - Pelosi G, et al. ΔNp63 (p40) and thyroid transcription factor-1
immunoreactivity on small biopsies or cellbloc
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