Description
P504S (AMACR) is an essential enzyme in the β-oxidation of branched-chain fatty acids. Recently, P504S was identified through cDNA library subtraction and microarrays in malignant prostate tissues. High expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. The expression of P504S is also detected in two premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. Using P504S as a positive marker along with basal cell staining (34 βE12 or P63) as a negative marker could help to confirm the diagnosis of small focus of prostate carcinoma on needle biopsy.
Additional information
| Catalog No. | RMAB078 Concentrated, RMPD078 Prediluted |
|---|---|
| Clone | 13H4 |
| Isotype | Rabbit IgG |
| Immunogen | Human AMACR (P504S) polypeptide. |
| Species | Rabbit |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Prostate carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Xu J et. al. Canc Res. 2000; 60:1677
- Jiang Z et. al. Human Pathology. 2003; 34(8):792
- Jiang Z et. al. Am J Surg Pathol. 2001; 25(11):1397
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