Description
S100 belongs to the family of calcium binding proteins and S100A and S100B are two members of the S100 family. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. This antibody stains with S-100 protein. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast,salivary and sweat glands, as well as glial cells. A large number of welldifferentiated tumors of salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein. S100 is of great value in the identification of several neoplasms, particularly melanomas and their metastases.
Additional information
| Catalog No. | Mob377 Concentrated, PDM194 Prediluted |
|---|---|
| Clone | 4C4.9 |
| Immunogen | Purified bovine brain S100 protein |
| Isotype | IgG2a, kappa |
| Species | Mouse |
| Positive Control Tissue | Melanoma |
| Pretreatment | HistoZyme (Manual/ Montage) |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Nishikawa et al. Identification of S100b protein as copper-binding
protein and its suppression of copper-induced cell damage. J Biol
Chem. 1997;272:23037–23041 - Leite MC, et al. Ammonia-induced alteration in S100B secretion
in astrocytes is not reverted by creatine addition. Brain Res Bull.
2006;70:179–185. - Broome AM, et al. S100 protein subcellular localization during
epidermal differentiation and psoriasis. J Histochem Cytochem.
2003;51:675–685
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