Description
Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2, they are differentially expressed depending on the functional activity of the muscle.
The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors
Additional information
| Catalog No. | Mob467 Concentrated, PDM175 Prediluted |
|---|---|
| Clone | SMMS-1 |
| Isotype | IgG1, kappa |
| Immunogen | Human uterus extract |
| Species | Mouse |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Appendix, Uterus |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Glukhova MA,et al; J Biol Chem 1990; 265(22):13042-13046.
- Lazard D, et al; Proc Natl Acad Sci USA 1993; 90:999-1003.
- Borrione AC, et al; Eur J Biochem 1989; 183:413-417.
- Benzonana G. et al.; Cell Motil. Cytoskel., 11, 260 (1988)
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