Description
SOX10 is widely expressed in normal human tissues including melanocytes and breast tissue. SOX10 is also an important marker in malignant tumors such as melanoma, breast carcinoma, gliomas, and benign tumors such as schwannomas.SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes and myoepithelial cells ofsalivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Additional information
| Catalog No. | Mob565 Concentrated, PDM565 Prediluted |
|---|---|
| Clone | 20B7 |
| Isotype | IgG1 |
| Immunogen | Human SOX10 recombinant protein |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Melanoma |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Mohamed A, et al. SOX10 Expression in malignant melanoma, carcinoma and normal tissues. Appl Immunohistochem Mol Morphol.2013; 21(6):506-10
- Mollaaghababa R, et al. The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia. Oncogene. 2003 May 19; 22(20):3024-34.
- Bondurand N, et al. Expression of the SOX10 gene during human development. FEBS Lett. 1998 Aug 7; 432(3):168-72.
- Bannykh SI, et al. Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. J Neurooncol. 2006 Jan; 76(2):115-27
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