Description
Solitary fibrous tumor (SFT) is a fibroblastic neoplasm of variable biologic potential that can arise at a wide range of anatomic sites. Almost all cases of (98%) including conventional, cellular, atypical, and malignant variants showed nuclear expression of STAT6. Staining for STAT6 was usually diffuse: 68% of cases showed reactivity for STAT6 in 75% of tumor cells. Further, the intensity of staining was strong in 67% of cases, moderate in 25%, and weak in only 7%. The heterogeneity of staining, both in terms of extent and intensity, which may be because of uneven tissue fixation or loss of antigenicity in older cases for which the unstained slides were stored for extended periods of time. All other tumor types examined were negative for STAT6, except for three dedifferentiated liposarcomas and one deep fibrous histiocytoma, which showed weak staining. STAT6 is therefore a highly sensitive and almost perfectly specific immunohistochemical marker for SFT, and can be helpful to distinguish this tumor type from histologic mimics.
Additional information
| Catalog No. | Mob605R, PDM605R |
|---|---|
| Clone | D-1 |
| Species | Mouse |
| Isotype | IgG2b |
| Immunogen | A systhetic peptide corresponding to amino acids 799-823 at the C-terminus |
| Positive Control Tissue | Solitary fibrous tumor |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | RUO (Europe) |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
| Format | Tissue Culture Supernatant |
| Description/Type | Mouse Monoclonal Antibody |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Mod Pathol 2014;27:390
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