Description
This antibody recognizes a protein of 21kDA, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the protolytic invasiveness of tumor cells and normal placental trophoblast cells.
Additional information
| Catalog No. | Mob318, Mob318R – Concentrated, PDM318 |
|---|---|
| Clone | 3A4 |
| Isotype | IgG2a, kappa |
| Immunogen | BALB/C mice were injected with a synthetic peptide from the N-terminal region of human TIMP-2. |
| Species | Mouse |
| Cellular Localization | Cytoplasm and cell surface |
| Positive Control Tissue | Breast, Colon, Endometrial, HeLa cells, Normal Placenta, Prostate or Ovarian Carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Murray et al. 1998. Gut. 43(6):791-7.
- Jeffery et al. 2009. Histopathology. 54(7):820-8
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