TNF-alpha (Tumor Necrosis Factor alpha)

This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-α (Tumor Necrosis Factor-alpha). Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kDa and can be expressed as a free molecule, also TNF-α is generated as a precursor form called transmembrane TNF-α can be expressed as a cell surface type II polypeptide consisting of 233 amino acid residues molecular weight 26 kDa. TNF-α is an important cell-signaling component of the immune system. It is a protein secreted by LPS stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-α is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

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REFERENCES

• Bradley JR. TNF-mediated inflammatory disease. J Pathol 2008;214:149-60.
• Pennica D, et al. Human tumor necrosis factor: precursor structure, cDNA cloning, expression, and homology to lymphotoxin.Nature 1984;312:724-9.
• Shealy DJ, et al.. Anti-TNF antibodies: lessons from the past,roadmap for the future. Handb Exp Pharmacol. 2008;(181):101-29.
•  Carswell EA, et al. An endotoxin-induced serum factor that causes necrosis of tumors. PNAS (USA) 1975, 72:3666–3670.
• Bebok Z; et al. Prognostic relevance of transforming growth factor alpha (TGF-alpha) and tumor necrosis factor alpha (TNF-alpha) detected in breast cancer tissues by immunohistochemistry. Breast Cancer Research and Treatment, 1994, 29(3):229-35.