Description
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. Uroplakins are markers of terminally differentiated urothelium. Uroplakin II (UPII) is a newly described sensitive marker for urothelial carcinoma (UC). The expression profile of UPII in different types of UC and its utility in the diagnostic setting are needed.
Additional information
| Catalog No. | PDR177 Prediluted, RP177 Concentrated |
|---|---|
| Clone | Polyclonal |
| Immunogen | Peptide-KLH conjugate |
| Species | Rabbit |
| Cellular Localization | Cytoplasmic and Membranous |
| Positive Control Tissue | Bladder Carcinoma |
| Pretreatment | Tris EDTA Buffer pH9.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Polyclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Moll R, et al. Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas. Am J Pathol. 1995; 147:1383-97
- Olsburgh J, et al. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. J Pathol. 2003; 199:41-9
- Parker DC, et al. Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokerain and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomas. Am J Surg Pathol. 2003; 27:1-10
- Ohtsuka Y, et al. Loss of uroplakin III expression is associated with a poor prognosis in patients with urothelial carcinoma of the upper urinary tract. BJU Int. 2006; 97:1322-6.
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