Description
BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumor suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway. Germline mutations of BAP1 confer increased susceptibility for the development of several tumors, including uveal melanoma, epithelioid atypical Spitz tumors, cutaneous melanoma, and mesothelioma. Somatic BAP1 mutations are seen in cutaneous melanocytic tumors (epithelioid atypical Spitztumors and melanoma), uveal melanoma, mesothelioma, clear cell renal cell carcinoma, and other tumors. BAP1 immunohistochemistry is particularly useful in differentiating malignant mesothelioma (nuclear negative) vs. reactive mesothelial proliferation (nuclear positive).
Additional information
| Catalog No. | Mob603 Concentrated, PDM603 Prediluted |
|---|---|
| Clone | BAP1/2667 |
| Isotype | IgG2b, kappa |
| Immunogen | Recombinant human BAP1 protein fragment (aa191-aa326, exact sequence is proprietary) |
| Species | Mouse |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | Tris EDTA Buffer pH9.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Description/Type | Mouse Monoclonal Antibody |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Cellular Localization | Nuclear and Cytoplasmic |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
I. Ventii, K.H., et al. Cancer Res.68: 6953-6962.
II. Andrici, J., et al. Hum. Pathol. 51: 9-15.
III. Wu, D., et al. Ann. Diagn. Pathol. 26: 31-37.
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