C4D

This MAb is specific to Comple ment 4d (C4d) and it reacts with the secreted as well as cell-bound C4d. C4d is a degradation product of the activated complement factor C4b. Comple ment 4b is typically activated by binding of Absto specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Comple ment 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibodymediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium,this component can be detected in peritubular capillariesin chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.

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REFERENCES

• Collins AB et. al. J Am Soc Nephrol. 1999;10(10):2208-14.
• Racusen LC et. al. Am J Transplant. 2003;3(6):708-14.
• Sacks SH et. al. Curr Opin Nephrol Hypertens. 2002;11(6):627-8.