Description
This antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Anti-CD34 labels more than 85% of angiosarcoma and Kaposi’s sarcoma, but with a lower specificity.
Additional information
| Clone | QBEND/10 |
|---|---|
| Isotype | IgG1, kappa |
| Immunogen | Detergent solubilized vesicular suspension prepared from human term placenta. |
| Species | Mouse |
| Cellular Localization | cell membrane |
| Positive Control Tissue | Kidney, Tonsil |
| Pretreatment | Citrate Buffer pH 6.0 (Manual/ Montage) |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Frolova, Let al., Monoclonal antibody IC0-115 to human CD34 antigen. Herald of the Cancer Research Center of RAMS. Sapp!, p. 10-12, 1994.
- Miettinen M, et aLGastrointestinal stromal tumors of the stomach: a dinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am.( Sorg Pothol. 2005 lan;29 (1):52-68.
- Ryan P, et al. Human herpesvirus 8 (HHV-8) detected in two patients with Kaposi’s sarcoma-like pyagenk granuloma. J Oin hallo!. 2002 Aug;SS (8):619-22.
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