Description
The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.
Additional information
| Catalog No. | Mob572 Concentrated, PDM572 Prediluted |
|---|---|
| Clone | 405-9A11 |
| Isotype | IgG1, kappa |
| Immunogen | Last 19 amino acids at the carboxyterminus of the human membranebound PD-L1 polypeptide, coupled to KLH. |
| Species | Mouse |
| Cellular Localization | cell membrane |
| Positive Control Tissue | Lung squamous Ca |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Cree IA, et al. PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation. Histopathology. 2016;69(2):177–186.
- Garon EB, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med.2015;372(21):2018–2028.
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