CD10 has widespread distribution throughout various tissues with a large number of applications. However it must be used with caution, since staining can be non-specific. It is a marker of pre-B lymphocytes, and therefore seen in acute lymphoblastic leukemia, diffuse large cell lymphoma (germinal center type), Burkitt lymphoma and follicular lymphoma. It can be very useful to identify endometrial stromal tumors and endometriosis. It shows canalicular staining in hepatocellular carcinoma. In renal tumors, it separates eosinophilic clear cell carcinoma (pos) from chromophobe carcinoma (neg). In the breast, it can identify myoepithelial cells and myofibroblastoma. In the GYN setting, it can separate primary clear cell carcinoma (neg) from metastatic renal clear cell carcinoma (pos). In the pancreas it identifies solid and papillary neoplasm.