Description
This antibody is specific to actin from smooth muscles. It does not stain cardiac or skeletal muscle; however, It does stain myofibroblasts and myoepithelial cells. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.
Additional information
| Catalog No. | Mob001 Concentrated, PDM003 Prediluted |
|---|---|
| Clone | 1A4 |
| Isotype | IgG2a, kappa |
| Immunogen | BALB/C mice were injected with N-terminal decapeptide of α-smooth muscle actin. |
| Species | Mouse |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Colon, Leiomyoma |
| Pretreatment | EDTA Buffer pH 8.0 (Manual/ Montage) |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Conc Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
REFERENCES
REFERENCES
- Skalli et al. Lab Invest 60: 275, 1989.
- Skalli et al. J Histo Chem 37: 315, 1989
- O’Byrne et al. Br J cancer 82: 1427, 2000
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