Description
Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node-negative and node-positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.
Additional information
| Catalog No. | PDR004 Prediluted, RP004 Concentrated |
|---|---|
| Clone | Rabbit |
| Isotype | _ |
| Immunogen | Cathepsin D isolated from human liver. |
| Species | Rabbit |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Breast carcinoma, Prostate |
| Pretreatment | None |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Polyclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Garcia et al. J Steroid Biochem 27: 429, 1987.
- Henry et al. Cancer 65: 265, 1990.
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