Description
CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This antibody can be used for immnophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues.
Additional information
| Clone | L26 |
|---|---|
| Isotype | IgG2a, kappa |
| Immunogen | BALB/C mice were injected with human tonsil B cells. |
| Species | Mouse |
| Cellular Localization | cell membrane, Cytoplasmic |
| Positive Control Tissue | Tonsil |
| Pretreatment | Citrate Buffer pH 6.0 (Manual/ Montage) |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a cell culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Ishii et al. Clin Exp Immunol 58: 183, 1984.
- Mason et al. Am J Pathol 136: 1215, 1990.
- Cartun et al. Am J Pathol 129: 415, 1987.
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