Description
The Clone LN10 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone LN10 recognizes T cells in thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliestsigns of commitment to the T cell lineage.
Additional information
| Clone | LN10 |
|---|---|
| Isotype | IgG1 |
| Immunogen | Prokaryotic recombinant protein corresponding to C-terminal region of CD3. |
| Species | Mouse |
| Cellular Localization | cell membrane |
| Positive Control Tissue | Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 (Manual/ Montage) |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Conc Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Steward M, Bishop R, Piggott NH et al. Production and
characterization of a new monoclonal antibody effective in
recognizing the CD3 T-cell associated antigen in formalin-fixed
embedded tissue. Histopathology 1997; 30, 16–22. - Williamson SLH, Steward M, Milton I et al. New monoclonal
antibodies to the T cell antigens CD4 and CD8: Production and
characterization in formalin-fixed, paraffin-embedded tissue.
American Journal of Pathology 1998; 152 (6), 1421–1426. - Leong FJW-M and Leong AS-Y. Essential markers in malignant
lymphoma: a diagnostic approach. The Journal of
Histotechnology 2002; 25(4), 215–227. - Krynitz B, Rozell B and Lindelof B. Differences in peritumoral
inflammatory skin infiltrate between squamous cell carcinomas
in organ transplant recipients and immunocompetent patients.
Acta Dermato Venerologica. 2010; 90:379-385.
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