Description
The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract.
Additional information
| Clone | EP25 |
|---|---|
| Isotype | Rabbit IgG |
| Immunogen | A synthetic peptide corresponding to residues near the C-term of humanCDX-2 protein |
| Species | Rabbit |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Colon Colon Adenocarcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rabbit Monoclonal Antibody |
| Format | This antibody is affinity purified and diluted in 10 mM Phosphate buffered saline (PBS), pH 7.5 containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3) as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Drummond F, et al. Ann Hum Genet 61(5):393-400
- Gregory PA, et al. Pharmacogenet Genomics 16(7):527-36, 2006
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